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They can. Larger garments often have higher blank costs, and extended-size availability varies by brand and color.
Some printers charge for artwork cleanup, screens, digitizing, color separation or production setup; others build those costs into the quote.
Standardizing the garment, shirt color and artwork usually reduces complexity and avoids small split runs.
The main drivers are garment choice, quantity, artwork, print dimensions, number of print locations, personalization, deadline and fulfillment requirements.
There is no universal definition, but many buyers begin seeking bulk pricing around 10 to 25 shirts.
Minimums vary by printer and production method. Digital and DTF processes can support smaller runs, while other methods may be priced around larger quantities.